SIMAP
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Introduction
SIMAP (Similarity Matrix of Proteins) is a public database of protein similarities that plays a key role in bioinformatics research. The SIMAP database contains substantially all currently published protein sequences and is continuously updated. But as the number of sequences grows, so also does the computational effort required to keep the similarities matrix up to date-- the computational effort to calculate the similarity data depends on the square of the number of sequences. Please help to update this vital resource by calculating protein similarities on your computer. The computing power you donate supports a wide range of biological research projects that make use of SIMAP data.

Contents

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Videos

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Science

[The Science section might (or might not) be divided into two parts: {1} general discussion of the field, and then {2} a discussion of the project's specific endeavor. For instance, in LHC@home, we might have {1} "Science of the Large Hardon Collider" and then {2} "Science of LHC@home"

The above is desirable, because in most cases, the field of research is really fascinating, and presenting this in broad terms-- outlining the big questions-- can make it easier to understand the particulars of the project and why it is important.]

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Results

  1. Rattei T, Tischler P, Arnold R, Hamberger F, Krebs J, Krumsiek J, Wachinger B, Stümpflen V, Mewes W. SIMAP--structuring the network of protein similarities. Nucleic Acids Res. 2008 Jan;36(Database issue):D289-92. Epub 2007 Nov 23.
  2. Rattei T, Arnold R, Tischler P, Lindner D, Stümpflen V, Mewes HW. SIMAP: the similarity matrix of proteins. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D252-6.
  3. Arnold R, Rattei T, Tischler P, Truong MD, Stümpflen V, Mewes W. SIMAP--the similarity matrix of proteins. Bioinformatics. 2005 Sep 1;21 Suppl 2:ii42-6.
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Links of Interest

[Why recreate the wheel; there are lots of great sources out there.; a good list of sources can be really useful to the reader.]

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SIMAP In the Classroom

[For each project, please add a "[Projectname] in the Classroom" section-- with a link to Volunteer Computing In the Classroom and an article named "[Projectname] in the Classroom". (Then please add "[Projectname] in the Classroom" to the list on the main Education page.)]

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